SAN DIEGO, August 24, 2011 – Genomatica, Inc. announced today that it has filed a registration statement on Form S-1 with the U.S. Securities and Exchange Commission (SEC) relating to a proposed initial public offering of shares of its common stock. All shares of the common stock to be sold in the offering will be offered by Genomatica. The number of shares to be offered and the price range for the offering have not yet been determined.

Morgan Stanley & Co. LLC, J.P. Morgan Securities LLC and Jefferies & Company, Inc. will be joint book-running managers for the offering.  Piper Jaffray & Co. will be a passive book-running manager and Raymond James & Associates, Inc. will be a co-manager for the offering. The offering will be made only by means of a prospectus. A copy of the preliminary prospectus relating to the offering, when available, may be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York, 10014, or by email at [email protected], or from J.P. Morgan Securities LLC, Attention: Broadridge

Financial Solutions, 1155 Long Island Avenue, Edgewood, New York, 11717, or by telephone at (866) 803-9204, or from Jefferies & Company, Inc., Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, New York, 10022, or by telephone at (877) 547-6340, or by email at [email protected].

A registration statement relating to these securities has been filed with the SEC, but has not yet become effective. These securities may not be sold nor may offers to buy be accepted prior to the time the registration statement becomes effective. This release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About Genomatica

Genomatica  is a  technology  leader  for  the global chemical  industry. It delivers new,  transformative manufacturing processes that enable  its  partners  to  produce  intermediate  and  basic  chemicals from renewable feedstocks. Intermediate and basic  chemicals  serve  as  the  basis  for  making substantially  all of the products that make modern life possible, and  Genomatica’s  processes enable the production of the exact same chemicals that are at the core of the chemical industry.